| Function | Keyboard Shortcut |
| Set LO frequency on tuned frequency (center) | C |
| Enter new LO frequency | Ctrl+O or L |
| Enter new Tune frequency | Ctrl+T or T |
| Enter new Quick Tune frequency (auto LO) | Ctrl+Q or Q |
| Fast frequency input | 1 - 9 |
| Switch between LO A and B | Ctrl+V |
| Frequency Manager + Bands | Ctrl+B |
| Increase LO frequency by visible spectrum bandwidth | Ctrl+PageUp |
| Decrease LO frequency by visible spectrum bandwidth | Ctrl+PageDown |
| Select MouseWheelStep | Ctrl+Home or Menu |
| Increase Tune frequency by MouseWheelStep | Ctrl+Up |
| Decrease Tune frequency by MouseWheelStep | Ctrl+Down |
| Increase LO frequency by MouseWheelStep | Ctrl+Right |
| Decrease LO frequency by MouseWheelStep | Ctrl+Left |
| Switch Mode to AM | Ctrl+A |
| Switch Mode to CW | Ctrl+C |
| Switch Mode to DRM | Ctrl+D |
| Switch Mode to ECSS | Ctrl+E |
| Switch Mode to FM | Ctrl+F |
| Switch Mode to LSB | Ctrl+L |
| Switch Mode to USB | Ctrl+U |
| NB – Noise Blanker | B |
| NR – Noise Reduction | R |
| Notch Filter (Beat Cancel) | N |
| AGC (fast/mid/slow/off) | G |
| Mute on/off | M |
| Volume | +/- |
| Swap positions of Waterfall/Spectrum | S |
| Collapse Mode | Shift+C |
| Zoom RF Spectrum | Ctrl+'+' |
| UnZoom RF Spectrum | Ctrl+'-' |
| Reset RF Spectrum Zoom to full bandwidth | Ctrl+0 |
| Increase FFT Resolution Bandwidth (RBW) | Ctrl+'*' |
| Decrease FFT Resolution Bandwidth (RBW) | Ctrl+'/' |
| S-meter calibration: Increase level | Shift+Up |
| S-meter calibration: Decrease level | Shift+Down |
| S-meter calibration: Reset level | Shift+Home |
| ZAP | Z |
| AFC | F |
| CW Peak | P |
| Despreading | D |
| Switch between RX and TX | Space |
| TX mode: Switch CW carrier tone on/off | Return |
| Rewind WAV file | Shift+W |
| Switch WAV file looping | Shift+L |
| Record WAV file | Shift+R |
| Play WAV file | Shift+P |
| Stop Playback/Recording | Shift+S |
| Pause Playback/Recording | Shift+B |
| Show GUI of ExtIO-DLL | H |
| Start/Stop HDSDR | F2 |
| Minimize HDSDR | F3 |
| Exit HDSDR | F4 |
| Open sound card selection dialog | F5 |
| Open sampling rate dialog | F6 |
| Open Options menu | F7 |
| Info / Update | F9 |
| Full Screen | F11 |
| Boss Key | Pause |